Endocrine Abstracts

In the gastroentero-pancreatic tract, a spectrum of neuroendocrine tumors (NET) exists, including low grade tumors (carcinoid), intermediate grade malignant carcinoid, and high grade poorly differentiated carcinomas of the small and large cell types. In year 2000, the WHO presented a classification scheme for all NETs, but mostly applied to gastroentero-pancreatic tumors. This term carcinoid was replaced by (neuro)endocrine tumor, malignant carcinoid by well differentiated (ne...

Background: Typing somatostatin receptor (SSTR) expression in neuroendocrine tumors (NETs) is of relevance to target an octreotide-based diagnostic approach and treatment. The expanding use of immunohistochemistry to detect SSTR is to date not paralleled by an accurate methodological setting and standardized interpretation of the results.Objective: A multicentric study was designed to compare SSTR immunohistochemical expression with in vivo scinti...